Characterization of an aryl hydrocarbon receptor from a cetacean
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Characterization of an aryl hydrocarbon receptor from a cetacean an approach for assessing contaminant susceptibility in protected species by Brenda A. Jensen

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Published by Woods Hole Oceanographic Institution in Woods Hole, Mass .
Written in English


  • Cetacea -- Effect of pollution on.,
  • White whale.,
  • Dioxins -- Physiological effect.,
  • Dioxins -- Toxicology.,
  • Polycyclic aromatic hydrocarbons.,
  • Marine pollution -- Physiological effect.

Book details:

Edition Notes

Statementby Brenda A. Jensen.
SeriesMIT/WHOI -- 00-28., MIT/WHOI (Series) -- 2000-28.
ContributionsMassachusetts Institute of Technology., Woods Hole Oceanographic Institution.
The Physical Object
Pagination199 p. :
Number of Pages199
ID Numbers
Open LibraryOL16012338M

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cDNA Cloning and Characterization of a High Affinity Aryl Hydrocarbon Receptor in a Cetacean, the Beluga, Delphinapterus leucas Article in Toxicological Sciences 64(1) December with. "Characterization of AhR agonists reveals antagonistic activity in European herring gull (Larus Argentatus) eggs " Science of the total environment Paper IV Muusse, M., Langford, K., Tollefsen, K.-E.,. and Thomas, K.V., Naturally occurring compounds are potential aryl hydrocarbon receptor agonists in Norwegian mosses. Manuscript. Aryl Hydrocarbon Receptor. The aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix-period-aryl hydrocarbon receptor nuclear translocator-single-minded (bHLH-PAS) family of transcription factors, which act as biological sensors by initiating gene expression programs in response to endogenous and exogenous signals [1]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin is almost exclusively mediated through this by:

  Role of Aryl Hydrocarbon Receptor in the Development of Lymphoid Follicles. AhR has been found to be expressed in RORγt + ILC. 3, 21, 22 In fact, using Ahr-deficient mice we and others observed that AhR plays an essential role for RORγt + ILC function and maintenance. The absence of AhR leads to failure to form intestinal lymphoid clusters, such as CP and ILF. 22, 23 Cited by:   2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related planar halogenated aromatic hydrocarbons are widespread contaminants of the environment, causing an extensive range of adverse effects in various effects are initiated by ligand binding to the aryl hydrocarbon receptor (AhR), a cytoplasmic transcription factor (Poland and Knutson, ; Schmidt and Bradfield, ).Cited by: AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene. The protein is a member of the FKBP s: AIP, ARA9, FKBP16, FKBP37, SMTPHN, XAP .   The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of the carcinogen 2,3,7,8 Cited by:

  The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that contains a basic helix-loop-helix (bHLH) and Per-ARNT-Sim (PAS) domain (Furness et al., ).Although a variety of compounds including both xenobiotics and naturally occurring compounds are known as ligands of AHR, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in dioxins and dioxin-related Cited by: Key Words Ah receptor, 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD, Ah receptor ligands, CYP1A1 Abstract The induction of expression of genes for xenobiotic metabolizing en-zymes in response to chemical insult is an adaptive response found in most organisms. In vertebrates, the AhR is one of several chemical/ligand-dependent intracellular re-. Atlantic tomcod from the Hudson River, USA, are resistant to cytochrome PA1 (CYP1A1) mRNA induction and early life stage toxicities induced by coplanar polychlorinated biphenyls (PCBs) or tetrach Cited by: The Aryl Hydrocarbon (Dioxin) Receptor: Promiscuity in Activation and Diversity in Response. M.S. Denison. 1, J.E. Bohonowych. 1, Bin Zhao. 1, Dal-Ho Han.